Hypermobile EDS is characterized primarily by joint hypermobility affecting both large and small joints, which may lead to recurrent joint dislocations and subluxations (partial dislocation). In general, people with this type have soft, smooth and velvety skin with easy bruising and chronic pain of the muscles and/or bones.

Classical EDS is associated with extremely elastic (stretchy), smooth skin that is fragile and bruises easily; wide, atrophic scars (flat or depressed scars); and joint hypermobility.  Hypotonia and delayed motor development may occur.

Vascular EDS is characterized by thin, translucent skin that is extremely fragile and bruises easily. Arteries and certain organs such as the intestines and uterus are also fragile and prone to rupture. People with this type typically have short stature; thin scalp hair; and characteristic facial features including large eyes, a thin nose, and lobeless ears. Other common features include tendon and/or muscle rupture; acrogeria (premature aging of the skin of the hands and feet); pneumothorax (collapse of a lung).

Kyphoscoliosis EDS is associated with severe hypotonia at birth, delayed motor development, progressive scoliosis (present from birth).

Arthrochalasia EDS is characterized by severe joint hypermobility and congenital hip dislocation . Other common features include fragile, elastic skin with easy bruising; hypotonia; kyphoscoliosis and mild osteopenia.

Dermatosparaxis EDS is associated with extremely fragile skin leading to severe bruising and scarring; saggy, redundant skin, especially on the face; and hernias.

Brittle Cornea Syndrome (BCS) characterized by thin cornea, early onset progressive keratoglobus; and blue sclerae.

Classical-like EDS (clEDS) characterized by skin hyperextensibility with velvety skin texture and absence of atrophic scarring, generalized joint hypermobility (GJH) with or without recurrent dislocations (most often shoulder and ankle), and easily bruised skin or spontaneous ecchymoses (discolorations of the skin resulting from bleeding underneath).

Spondylodysplastic EDS (spEDS) characterized by short stature (progressive in childhood), muscle hypotonia (ranging from severe congenital, to mild later-onset), and bowing of limbs.

Musculocontractural EDS (mcEDS) characterized by congenital multiple contractures, clubfoot, craniofacial features, and skin features such as skin hyperextensibility, easy bruisability, and skin fragility with atrophic scars.

Myopathic EDS (mEDS) is characterized by  congenital muscle hypotonia, and/or muscle atrophy, that improves with age,  joint contractures of the knee, hip and elbows and hypermobility of the ankles, wrists, feet and hands).

Periodontal EDS (pEDS) characterized by severe and intractable early onset gum disease of early onset.

Cardiac-valvular EDS (cvEDS) characterized by severe progressive cardiac-valvular problems (aortic valve, mitral valve), skin problems (hyperextensibility, atrophic scars, thin skin, easy bruising) and joint hypermobility.